Evidence map›Paper›PMID 42877780›Full record

ArticleIEEE International Conference on Omni-layer Intelligent Systems : COINS. IEEE International Conference on Omni-layer Intelligent Systems2026

Weakly Supervised Learning of Oral Cavity Images for Separating Precancer from Cancer.

Zhiyun Xue, Niccolo Marini, Sivaramakrishnan Rajaraman, Zhaohui Liang, Sameer Antani

Abstract read
In one paragraph

Article in IEEE International Conference on Omni-layer Intelligent Systems : COINS. IEEE International Conference on Omni-layer Intelligent Systems, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhiyun XueDivision of Intramural Research, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-0644-385X
Niccolo MariniDivision of Intramural Research, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-5273-5741
Sivaramakrishnan RajaramanDivision of Intramural Research, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-0871-8634
Zhaohui LiangDivision of Intramural Research, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-9361-5535
Sameer AntaniDivision of Intramural Research, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-0040-1387

Funding

Machine learning and artificial intelligence research for clinical medical image processingZIALM010018 · NLM · NATIONAL LIBRARY OF MEDICINE · PI ANTANI, SAMEER · 2021 to 2025
$9.0M
Intramural NIH HHS ZIA LM010018
6 · The paper itself

Abstract

Early detection is crucial for reducing the morbidity and mortality associated with oral cancer. Visual examination of the oral cavity is the first step in screening for lesions that are cancer or precancer (i.e., the direct precursor to cancer). In contrast to existing work that uses image or lesion labels, we explore a weakly supervised method to address the situation where only patient-level labels are available. Specifically, we use multiple-instance learning (MIL) to classify patients with oral precancer versus cancer. Our approach involves three steps: image filtering, mouth detection, and patient-level classification. The method performs well on filtering and mouth detection and shows promising results in distinguishing precancer from cancer on an independent test set, demonstrating its potential as a proof-of-concept (PoC). We also discuss current limitations and future directions.

Indexed as

mouth region detectionmultiple instance learningoral cancer screeningoral cavity image evaluationweakly supervised learning

Identifiers

PMID42877780
PMCPMC13664155

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.