ArticleFrontiers in nutrition2026
Association of the triglyceride-cholesterol-body weight index (TCBI) with incident diabetes in Chinese adults: a population-based cohort study with non-linear and threshold analyses.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The triglyceride-cholesterol-body weight index (TCBI) is a simple composite nutritional marker. However, its association with incident diabetes remains unclear. We examined this association in Chinese adults, focusing on non-linear and threshold effects. Methods: This retrospective cohort study included 206,085 adults without baseline diabetes. TCBI was calculated as (TG × TC × body weight) / 1,000. We used Cox regression, restricted cubic splines, and segmented regression for analysis. Results: During follow-up, 4,093 participants developed incident diabetes. Higher TCBI was consistently associated with an increased risk of incident diabetes. In the fully adjusted model, each 1-SD increase in TCBI was associated with a 13% higher risk of incident diabetes (HR = 1.13, 95% CI: 1.12-1.14; Conclusions: These findings suggest that TCBI may represent an accessible composite metabolic indicator associated with diabetes risk; however, whether TCBI provides additional information beyond established metabolic indicators and whether the identified threshold has clinical relevance require further validation in diverse populations.
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