Evidence map›Paper›PMID 42877758›Full record

ArticleEuropean heart journal open2026

Circulating anti-Ro/Sjögren's syndrome-related antigen A antibodies and risk of heart rate-corrected QT interval prolongation: a meta-analysis.

Pietro Enea Lazzerini, Mark Markovich Melamud, Evgeny Alexandrovich Ermakov, Vadim Vyacheslavovich Konkov, Valentina Nikolaevna Buneva, Riccardo Accioli, Alessandra Cartocci, Anna Cantore, Viola Salvini, Decoroso Verrengia and 3 more

Abstract read
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In one paragraph

Article in European heart journal open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Pietro Enea LazzeriniDepartment of Medical Sciences, Surgery and Neurosciences, University of Siena, Viale Bracci 14, Siena 53100, Italy.ORCID https://orcid.org/0000-0001-6721-1214
Mark Markovich MelamudLaboratory of Repair Enzymes, Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 8 Lavrentyev Avenue, Novosibirsk 630090, Russia.ORCID https://orcid.org/0000-0003-4276-4597
Evgeny Alexandrovich ErmakovLaboratory of Repair Enzymes, Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 8 Lavrentyev Avenue, Novosibirsk 630090, Russia.ORCID https://orcid.org/0000-0002-1084-6419
Vadim Vyacheslavovich KonkovLaboratory of Repair Enzymes, Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 8 Lavrentyev Avenue, Novosibirsk 630090, Russia.ORCID https://orcid.org/0009-0001-1532-0985
Valentina Nikolaevna BunevaLaboratory of Repair Enzymes, Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 8 Lavrentyev Avenue, Novosibirsk 630090, Russia.ORCID https://orcid.org/0000-0003-2556-979X
Riccardo AccioliDepartment of Medical Sciences, Surgery and Neurosciences, University of Siena, Viale Bracci 14, Siena 53100, Italy.ORCID https://orcid.org/0000-0003-1983-4040
Alessandra CartocciDivision of Internal Medicine and Geriatrics, Electroimmunology Unit, University of Siena, Viale Bracci 14, Siena 53100, Italy.
Anna CantoreDivision of Internal Medicine and Geriatrics, Electroimmunology Unit, University of Siena, Viale Bracci 14, Siena 53100, Italy.ORCID https://orcid.org/0009-0004-6890-3502
Viola SalviniDepartment of Medical Sciences, Surgery and Neurosciences, University of Siena, Viale Bracci 14, Siena 53100, Italy.
Decoroso VerrengiaDepartment of Medical Sciences, Surgery and Neurosciences, University of Siena, Viale Bracci 14, Siena 53100, Italy.ORCID https://orcid.org/0000-0002-8227-6339
Maurizio AcampaDepartment of Medical Sciences, Surgery and Neurosciences, University of Siena, Viale Bracci 14, Siena 53100, Italy.ORCID https://orcid.org/0000-0003-4149-1785
Pier Leopoldo CapecchiDepartment of Medical Sciences, Surgery and Neurosciences, University of Siena, Viale Bracci 14, Siena 53100, Italy.ORCID https://orcid.org/0000-0001-7021-7764
Mohamed BoutjdirDepartment of Medicine, Cell Biology and Pharmacology, Cardiovascular Research Program, VA New York Harbor Healthcare System, SUNY Downstate Health Sciences University, 445 Lenox Rd, Brooklyn, New York, NY 11203, USA.ORCID https://orcid.org/0000-0002-6068-223X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Accumulating evidence indicates that anti-Ro/Sjögren's syndrome-related antigen A (SSA) antibodies, specifically the anti-Ro/SSA-52kD subtype, can promote heart rate-corrected QT interval (QTc) prolongation by inhibiting the hERG-K Methods and results: A systematic review was performed for clinical studies comparing QTc in anti-Ro/SSA-positive vs. -negative subjects. Standardized mean differences (SMDs) and odds ratios (ORs) were compared using random effects models. The risk of bias was assessed using RoBANS2, Egger's test and contour-enhanced funnel plots. Twenty-five studies were included, pooling 2122 anti-Ro/SSA-positive and 8865 anti-Ro/SSA-negative subjects. Overall, anti-Ro/SSA-positivity is associated with a longer QTc [SMD = 0.36 (0.18-0.53), Conclusion: This meta-analysis supports the conclusion that circulating anti-Ro/SSA-antibodies

Indexed as

Anti-Ro/SSA-52kD antibodiesAnti-Ro/SSA antibodiesConnective tissue diseasesQTc prolongationQTc values

Identifiers

PMID42877758
PMCPMC13663800

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.