ReviewArchives of medical science : AMS2026
Associations between enlarged perivascular spaces and clinical manifestations: a meta-analysis.
Review in Archives of medical science : AMS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Enlarged perivascular spaces (EPVS) are ubiquitous in the elderly and have an insidious onset. Their correlation with clinical symptoms is easily overlooked and controversial. We conducted a meta-analysis to investigate the clinical outcomes associated with EPVS. Methods: Relevant studies published up to April 2022 were extracted from PubMed, Embase, Cochrane, OVID, and Web of Science. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to estimate the strength of the associations. Results: Of the 6622 articles identified, 32 studies were eligible, including a total of 19,987 people. EPVS were associated with an increased risk of cognitive impairment (OR = 1.60, 95% CI: 1.39-1.81), motor impairment (OR = 2.24, 95% CI: 1.22-3.25), sleep disturbance (OR = 1.81, 95% CI: 1.34-2.28), and depressive symptoms (OR = 1.54, 95% CI: 1.14-1.95), but was not significantly associated with the occurrence of stroke (OR = 0.97, 95% CI: 0.74-1.21). Results of subgroup analysis showed that basal ganglia (BG) EPVS were more strongly associated with cognitive impairment (OR = 2.19, 95% CI: 1.72-2.65) and sleep disturbance (OR = 1.74, 95% CI: 1.20-2.29). Conclusions: Our findings suggest that EPVS are associated with cognitive impairment, motor impairment, sleep disturbance, and depressive symptoms. These findings may provide a basis for further investigation of the clinical significance of EPVS.
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