Evidence map›Paper›PMID 42877683›Full record

ArticleRSC chemical biology2026

Exploring the biocatalytic potential of wild-type split transketolases.

Alessia Tonoli, Silvia Anselmi, Yeke Ni, John M Ward, Helen C Hailes, Jack W E Jeffries

Abstract read
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Article in RSC chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alessia TonoliDepartment of Biochemical Engineering, University College London Bernard Katz Building, Gower Street London WC1E 6BT UK jack.jeffries.12@ucl.ac.uk.ORCID https://orcid.org/0000-0002-6032-407X
Silvia AnselmiDepartment of Chemistry, University College London 20 Gordon Street London WC1H 0AJ UK h.c.hailes@ucl.ac.uk.ORCID https://orcid.org/0000-0003-3087-7287
Yeke NiDepartment of Biochemical Engineering, University College London Bernard Katz Building, Gower Street London WC1E 6BT UK jack.jeffries.12@ucl.ac.uk.
John M WardDepartment of Biochemical Engineering, University College London Bernard Katz Building, Gower Street London WC1E 6BT UK jack.jeffries.12@ucl.ac.uk.ORCID https://orcid.org/0000-0002-4415-5544
Helen C HailesDepartment of Chemistry, University College London 20 Gordon Street London WC1H 0AJ UK h.c.hailes@ucl.ac.uk.ORCID https://orcid.org/0000-0001-5574-4742
Jack W E JeffriesDepartment of Biochemical Engineering, University College London Bernard Katz Building, Gower Street London WC1E 6BT UK jack.jeffries.12@ucl.ac.uk.ORCID https://orcid.org/0000-0003-4143-2339

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Split transketolases (split TKs) are an underexplored class of carboligases with potential for application in biocatalysis. Here, we investigate ten split TKs and reveal substantial functional heterogeneity, with marked differences in substrate scope, activity, enantioselectivity, and robustness. The enzymes accepted diverse acceptors, aliphatic and aromatic, while retaining the canonical (

Identifiers

PMID42877683
PMCPMC13663882

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.