ArticleFrontiers in veterinary science2026
Timosaponin AIII mitigates zearalenone-induced kidney injury in weaned piglets in association with TLR/MAPK signaling suppression.
Article in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Zearalenone (ZEN) is a common Fusarium mycotoxin that frequently contaminates feed and can induce kidney dysfunction in pigs. Timosaponin AIII (TSA), a steroidal saponin isolated from Anemarrhena asphodeloides Bunge, possesses anti-inflammatory and antioxidant properties. This study evaluated whether TSA supplementation alleviates ZEN-induced kidney injury in weaned piglets and examined its association with TLR4/MAPK signaling. Methods: Eighteen weaned female piglets were randomly assigned to three groups ( Results: ZEN exposure significantly reduced final body weight, ADFI, ADG, and kidney index, and increased F/G, serum CRE and BUN concentrations, and renal histopathological lesions ( Discussion: TSA supplementation is associated with the alleviation of ZEN-induced kidney injury in weaned piglets, concomitant with reduced inflammatory and apoptotic responses and selective modulation of TLR/MAPK downstream signaling, particularly JNK. However, due to the absence of a TSA-only control group, the lack of analytical verification of dietary ZEN and TSA concentrations, and the absence of direct pathway inhibitor, knockdown, or rescue experiments, these findings are correlative and cannot establish causality. Further studies incorporating TSA-only groups, verified feed concentrations, and pathway-specific interventions are needed to confirm the protective mechanism and safety of TSA.
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