Evidence map›Paper›PMID 42877632›Full record

ArticleTetrahedron letters2026

Design and synthesis of conformationally constrained Tn antigen mimics.

Camden Di Carlo, Frankie P McLaughlin, Lauren R Spina, Jose Paredes-Larios, Sophia Lee-Wlodek, Ernest G Nolen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tetrahedron letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Camden Di CarloDepartment of Chemistry, Colgate University, 13 Oak Drive, Hamilton, NY 13346, USA.
Frankie P McLaughlinDepartment of Chemistry, Colgate University, 13 Oak Drive, Hamilton, NY 13346, USA.
Lauren R SpinaDepartment of Chemistry, Colgate University, 13 Oak Drive, Hamilton, NY 13346, USA.
Jose Paredes-LariosDepartment of Chemistry, Colgate University, 13 Oak Drive, Hamilton, NY 13346, USA.
Sophia Lee-WlodekDepartment of Chemistry, Colgate University, 13 Oak Drive, Hamilton, NY 13346, USA.
Ernest G NolenDepartment of Chemistry, Colgate University, 13 Oak Drive, Hamilton, NY 13346, USA.

Funding

Design and Synthesis of O-GalNAc and O-Man Peptides for Biomedical StudiesR15GM123534 · NIGMS · COLGATE UNIVERSITY · PI NOLEN, ERNEST G · 2017 to 2017
$382k
NIGMS NIH HHS R15 GM123534
6 · The paper itself

Abstract

Conformationally constrained Tn antigen mimics have been designed with consideration of the role water plays in organizing the GalNAc with the peptide. The synthesis of the mimic is reported and employs a cross-metathesis to construct the carbon skeleton and a Tsuji-Trost cyclization to form the

Indexed as

C-linked GalNAcConformational constraintCross-metathesisOxime cyclizationTn antigen mimicZretentive Tsuji-Trost

Identifiers

PMID42877632
PMCPMC13662962

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.