Adipokine regulation of immune cell polarization in oral cancer and its impact on chemotherapy sensitivity.

Puguan Wang, Jiakai Qiao, Junnan Qi, Huen Li, Jiatong Li, Kunyu Lin, Bei Chang

Abstract readReview

In one paragraph

Review in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Puguan WangJilin Provincial Laboratory of Biomedical Engineering, Jilin University, Changchun, China.

Jiakai QiaoJilin Provincial Laboratory of Biomedical Engineering, Jilin University, Changchun, China.

Junnan QiJilin Provincial Laboratory of Biomedical Engineering, Jilin University, Changchun, China.

Huen LiJilin Provincial Laboratory of Biomedical Engineering, Jilin University, Changchun, China.

Jiatong LiJilin Provincial Laboratory of Biomedical Engineering, Jilin University, Changchun, China.

Kunyu LinJilin Provincial Laboratory of Biomedical Engineering, Jilin University, Changchun, China.

Bei ChangJilin Provincial Laboratory of Biomedical Engineering, Jilin University, Changchun, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral squamous cell carcinoma (OSCC) is the most common malignant tumor in the head and neck region. In locally advanced patients, neoadjuvant chemotherapy centered on cisplatin and 5-fluorouracil often leads to primary/acquired resistance, with a 5-year survival rate of less than 50%. Tumor microenvironment (TME) immunosuppressive remodeling is the core cause of chemotherapy failure. Adipokines secreted by cancer-associated adipocytes (CAAs) are the key mediators that link metabolic disorders, immune polarization and chemotherapy resistance. The adipokines leptin, adiponectin, chemerin, resistin, and GDF15 signal through pathways such as JAK2/STAT3, PI3K/AKT, NF-κB, and PPARγ to bidirectionally regulate the polarization phenotypes of tumor-associated macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), CD4

Indexed as

adipokineschemotherapy resistanceimmune cell polarizationoral squamous cell carcinomatumor-associated macrophagestumor microenvironment

Identifiers

PMID42877600

DOI10.3389/fonc.2026.1954382

PMCPMC13662762

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.