Trial reportFrontiers in neuroscience2026
Influence of a full-spectrum aqueous extract of black cardamom (Amomum subulatum Roxb.) fruits on focus/alertness and executive function: a randomized, double-blind, placebo-and active- controlled, 14-day comparative study in healthy working professionals.
Trial report in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
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Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Nootropics enhance cognitive functions, including memory, attention, alertness, mood, and reaction time, through diverse neurobiological mechanisms. Caffeine, one of the most widely consumed nootropics, improves cognitive performance primarily by promoting wakefulness and alertness; however, these effects are generally transient. Consequently, there is growing interest in plant-derived, food-grade nootropics that can provide sustained cognitive benefits with a favorable safety profile. In this context, the nootropic efficacy of a full-spectrum aqueous extract of black cardamom fruits (MA2-24), administered alone and in combination with caffeine, was evaluated in the clinical trial. Methods: This randomized, double-blind, placebo- and active-controlled, 4-arm parallel group study for 14 days included healthy participants randomized into four groups ( Results: Linear mixed-effects analyses revealed significant effects of treatment, study day, and post-dose assessment time on cognitive performance, with significant interaction effects across outcomes. Supplementation with MA2-24 improved cognitive performance, particularly in measures of attention, processing speed, cognitive flexibility, and executive function, as reflected by increased correct responses, faster reaction times, and fewer errors in the Shifting Attention, Symbol Digit Coding, and Stroop tests. Significant improvements with MA2-24 were observed during the early post-dose period (1-3 h) across multiple cognitive outcomes compared with placebo ( Conclusion: CNSVS tests demonstrated that MA2-24 possesses significant nootropic potential in domains of attention, cognitive flexibility, executive function and processing speed, as evidenced by increased correct responses, faster reaction times, and fewer errors when consumed both as a standalone intervention and in combination with caffeine. Clinical trial registration: https://ctri.nic.in/Clinicaltrials/pmaindet2.php?EncHid=MTE0NzIx&Enc=&userName=, identifier CTRI/2024/09/074472.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.