Evidence map›Paper›PMID 42877540›Full record

ArticleImaging neuroscience (Cambridge, Mass.)2026

Dynamic 18F-FDG PET characterizes age-related changes in fitted ventricular FDG kinetics in humans.

Zeyu Zhou, Tianyun Zhao, He Wang, Aaron Carretero Benites, John Gardus, Qiuting Wen, Yang Feng, Christine DeLorenzo, Ramin Parsey, Chuan Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Imaging neuroscience (Cambridge, Mass.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zeyu ZhouRadiology and Imaging Sciences, Emory University, Atlanta, GA, United States.ORCID https://orcid.org/0009-0001-6561-376X
Tianyun ZhaoRadiology and Imaging Sciences, Emory University, Atlanta, GA, United States.ORCID https://orcid.org/0009-0001-0021-7424
He WangRadiology and Imaging Sciences, Emory University, Atlanta, GA, United States.
Aaron Carretero BenitesRadiology and Imaging Sciences, Emory University, Atlanta, GA, United States.
John GardusPsychiatry and Behavioral Sciences, Stony Brook University, Stony Brook, NY, United States.
Qiuting WenRadiology and Imaging Sciences, Indiana University, Bloomington, IN, United States.ORCID https://orcid.org/0000-0002-7885-4036
Yang FengBiostatistics, New York University, New York, NY, United States.
Christine DeLorenzoBiomedical Engineering, Stony Brook University, Stony Brook, NY, United States.
Ramin ParseyPsychiatry and Behavioral Sciences, Stony Brook University, Stony Brook, NY, United States.
Chuan HuangRadiology and Imaging Sciences, Emory University, Atlanta, GA, United States.ORCID https://orcid.org/0000-0001-6052-0663

Funding

Advancing Personalized Antidepressant Treatment Using PET/MRIR01MH104512 · NIMH · STATE UNIVERSITY NEW YORK STONY BROOK · PI DELORENZO, CHRISTINE · 2015 to 2018
$2.9M
NIMH NIH HHS R01 MH104512
6 · The paper itself

Abstract

Ventricular cerebrospinal fluid (CSF) transport is an important component of intracranial solute movement and may contribute to glymphatic-associated transport pathways. However, clinically accessible methods for quantifying ventricular CSF tracer dynamics in humans remain limited. This study examined the potential of dynamic 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) for quantifying ventricular CSF tracer kinetics as an indirect measure of CSF transport by evaluating its association with age and clinical factors. We analyzed baseline dynamic 18F-FDG PET data from participants with major depressive disorder enrolled in a prior clinical trial. Time-activity curves extracted from the lateral ventricles were modeled using a variant of the single-tissue compartment kinetic model to estimate kinetic parameters describing effective tracer entry into (

Indexed as

AgingFluorodeoxyglucose F18Positron-Emission TomographyRadiopharmaceuticalsAdultAgedFemaleHumansKineticsMajor Depressive DisorderMaleMiddle AgedFluorodeoxyglucose F18Radiopharmaceuticalsagingdynamic 18F-FDG PETglymphatic-associated transportkinetic modelingmajor depressive disorderventricular tracer kinetics

Identifiers

PMID42877540
PMCPMC13662652

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.