Evidence map›Paper›PMID 42877533›Full record

ArticleFrontiers in urology2026

Case Report: Reappearance of spermatozoa following multicomponent lifestyle modification in men with previously diagnosed azoospermia: a case series.

Michael Enwere, Mohamed Toufic El-Hussein, Emmanuel Davies, Laurens Holmes

Abstract readCase Reports
In one paragraph

Article in Frontiers in urology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Michael EnwerePrimeLife360 Wellness, London, United Kingdom.
Mohamed Toufic El-HusseinAgeCare Research Chair in Older Adults Health, School of Nursing and Midwifery, Faculty of Health, Community and Education, Mount Royal University, Calgary, AB, Canada.
Emmanuel DaviesPrimeLife360 Wellness, London, United Kingdom.
Laurens HolmesPublic Health Institute, FAMU, Tallahassee, FL, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Azoospermia, defined as the absence of spermatozoa in the ejaculate, is a severe form of male infertility, and the potential effects of intensive lifestyle modification on sperm production remain uncertain. We describe three adult men whose available pre-intervention records reported azoospermia and who undertook a multicomponent lifestyle programme centred on a predominantly raw, whole-food, plant-based diet, prescribed hydration, progressive physical activity, sleep and stress-management guidance, reduced alcohol consumption, and avoidance of ultra-processed and animal-derived foods. Clinical records, serial semen analyses, and available hormonal assessments were retrospectively reviewed. Approximately 10 weeks after programme initiation, spermatozoa were detected in all three participants, with concentrations of 1.6, 2.0, and 2.2 × 10

Indexed as

azoospermiacase seriesmale infertilitymulticomponent lifestyle interventionsevere oligozoospermiaspermatogenesisweight losswhole-food plant-based (WFPB)

Identifiers

PMID42877533
PMCPMC13662741

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.