ArticleFrontiers in veterinary science2026
Establishment of an ultrasound-guided rabbit model of hepatic inflammatory pseudotumor and contrast-enhanced ultrasound pattern analysis.
Article in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: The aim of this study was to develop a rabbit model of inflammatory pseudotumor of the liver (IPTL) using an ultrasound-guided implantation technique and to assess its feasibility, safety, and imaging characteristics in comparison with a surgical embedding approach. Methods: Twenty-six New Zealand rabbits were randomly assigned to one of three groups: the ultrasound-guided implantation group (Experimental Group), the surgical embedding group (Surgical Group), or a blank control group. IPTL lesions were induced using a combination of gelatin sponge and Freund's complete adjuvant. Parameters assessed included operative duration, lesion modeling success rate, findings from conventional ultrasound and contrast-enhanced ultrasound (CEUS), laboratory indicators, and histopathological outcomes. Results: All animals survived without severe complications. The lesion modeling success rates were 90% in the Experimental Group and 95% in the Surgical Group ( Conclusion: The ultrasound-guided implantation technique is a safe, efficient, and reproducible method for modeling IPTL in rabbits. The resulting lesions exhibit histopathological and CEUS characteristics that closely resemble those observed in human IPTL, supporting its utility as an experimental platform for further research into the pathophysiology and imaging features of IPTL.
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