ArticleBalkan journal of medical genetics : BJMG2026
Identification of Peripheral Blood mIR-128-3p Molecular Signature in Children with Autism Spectrum Disorder.
Article in Balkan journal of medical genetics : BJMG, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
MicroRNAs (miRNAs) are key post-transcriptional regulators of gene expression. Given the dynamic nature of the peripheral blood transcriptome, profiling circulating miRNAs in autism spectrum disorder (ASD) represents a promising strategy for identifying novel disease-associated biomarkers. Large-scale miRNA expression profiling was performed using the μParaflo™ miRNA microarray assay on pooled RNA samples from 23 individuals with ASD and 21 healthy controls. Differential expression analysis (p < 0.05) identified several dysregulated miRNAs in peripheral blood, including miR-128-3p. Microarray findings for miR-128-3p were validated by quantitative reverse transcription PCR (qRT-PCR), which confirmed its significant downregulation in the ASD group. Target gene analysis using miRWalk indicated that miR-128-3p exerts multilevel regulatory effects across diverse biological processes. Notably, predicted and validated targets included genes involved in neuronal development (e.g.,
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