ArticleBioinformatics advances2026
DNA breathing and shape encode distinct mechanisms of transcription factor binding.
Article in Bioinformatics advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
9 authors.
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Abstract
Motivation: Interactions between transcription factors (TFs) and DNA play a key role in regulating gene expression. While these interactions are often viewed primarily as recognition of DNA sequence motifs, several studies have shown the limitation of this approach and highlighted the impact of physical properties of DNA. Prior studies have supported the importance of DNA shape features as determinant of TF-DNA recognition. Another physical property is DNA breathing, the spontaneous and transient opening of double-stranded DNA through thermal motions, which has not been systematically examined. Results: We analyzed Availability and implementation: Data and analysis code are available at https://doi.org/10.17605/OSF.IO/UAHBJ and https://github.com/TsuPeiChiu/DNAbreathing.
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Registered trials
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