ArticleThe Journal of clinical and aesthetic dermatology2026
A Randomized Clinical Trial: Daily Photoprotection With a Combined Sunscreen-Antioxidant Formulation Preserves Mitochondrial DNA Integrity in Human Facial Skin In Vivo.
Article in The Journal of clinical and aesthetic dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate whether a daily antioxidant-enriched sunscreen preserves mitochondrial DNA (mtDNA) integrity vs vehicle, whether habitual sunscreen users gain additional protection from antioxidants, and whether mtDNA swabs can detect individual-level responses.
methodsAdults completed a randomized, double-blind, vehicle-controlled 12-week trial. Cheek swabs collected at baseline and Week 12 underwent blinded quantitative polymerase chain reaction assays. mtDNA damage was expressed as ΔCt, where higher values indicate greater damage and a negative change reflects improved integrity. The primary outcome was change in ΔCt.
resultsForty-one participants provided valid samples (antioxidant sunscreen: n=19; vehicle: n=18). Mean ΔCt change favored the antioxidant sunscreen (-0.48 vs 0.35; LIMITATIONS: This was a single-site pilot study and lacked a no sunscreen-only comparator arm.
conclusionDaily use of an antioxidant-enriched sunscreen produced consistent molecular evidence of reduced mtDNA damage, including statistically significant within-participant improvement among habitual sunscreen users.
Indexed as
Identifiers
42877380PMC13668096What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.