ArticleJournal of Alzheimer's disease reports
Unraveling the brain-heart axis: Mendelian randomization study on the causal relationship between heart rate variability and dementia.
Article in Journal of Alzheimer's disease reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
Background: A growing number of observational studies have suggested a potential association between heart rate variability (HRV) and dementia. However, the causal nature of this relationship remains unclear. Objective: This study aims to investigate the causal relationship between HRV and dementia using two-sample Mendelian randomization (MR) analysis. Methods: Two-sample MR analysis was conducted to examine the causal effects of HRV phenotypes, including the peak-valley respiratory sinus arrhythmia or high frequency power (pvRSA/HF), the root mean square of the successive differences of inter beat intervals (RMSSD), and normal-to-normal inter-beat intervals (SDNN), on eight dementia phenotypes (any dementia, Alzheimer's disease [AD], early-onset AD, late-onset AD, Lewy body dementia [DLB], frontotemporal dementia [FTD], Parkinson's disease dementia [PDD], and vascular dementia [VaD]). Results: Genetically determined pvRSA/HF was associated with an elevated risk of DLB (odds ratio [OR] 1.53; 95% CI 1.04-2.25; Conclusions: Our study provides suggestive evidence that pvRSA/HF has a potential causal relationship with elevated risks of DLB and FTD. These findings contribute to a better understanding of the potential role of HRV in specific dementia subtypes.
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