ReviewJournal of Alzheimer's disease reports
Association of HIV infection with dementia and cognitive impairment: A systematic review and meta-analysis.
Review in Journal of Alzheimer's disease reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: With the widespread use of antiretroviral therapy, people living with HIV (PLWH) are experiencing increased life expectancy, accompanied by a growing burden of age-related comorbidities. Cognitive impairment and dementia have been increasingly reported among PLWH; however, epidemiological evidence regarding their association remains inconsistent. Objective: This systematic review and meta-analysis aimed to evaluate the association between HIV infection and the risk of dementia and cognitive impairment. Methods: We systematically searched PubMed, Embase, Web of Science, and the Cochrane Library from inception to March 4, 2026 for cohort studies investigating the association between HIV infection and dementia or cognitive impairment. Study selection, data extraction, and quality assessment using the Newcastle-Ottawa Scale were independently conducted by two reviewers. Heterogeneity across studies was assessed using Results: A total of 9 articles were eligible for this analysis. The pooled results showed that HIV infection was significantly associated with an increased risk of dementia and cognitive impairment (RR=2.07, 95% CI: 1.35, 3.17). Substantial heterogeneity was observed across studies ( Conclusions: This meta-analysis suggests that HIV infection is associated with an increased risk of dementia and cognitive impairment.
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