ArticleJournal of Alzheimer's disease reports
Dissecting the sex-dependent muscle-brain axis: Hippocampal subfields mediate the association between grip strength and cognition in amnestic mild cognitive impairment.
Article in Journal of Alzheimer's disease reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Grip strength has been increasingly recognized as a potential indicator of cognitive decline and is closely associated with hippocampal structure. However, whether this muscle-brain relationship differs by sex among individuals with amnestic mild cognitive impairment (aMCI) remains unclear. Objective: To explore sex-specific relationships among grip strength, hippocampal subfield volumes and cognitive function in aMCI. Methods: This case-control study enrolled 144 aMCI patients and 84 healthy controls, demographic, neuropsychological, grip-strength data and 3.0 T MRI images were collected. Principal component analysis (PCA), multivariate regression, Pearson correlation and mediation analyses were performed. Results: Significant differences were found in the volumes of 15 hippocampal subfields, education level, right grip strength and cognitive scores. A bilateral grip strength related factor extracted by PCA was significantly associated with global cognition, memory, language, executive function and emotional status. Sex-stratified analyses revealed sex-specific correlations between grip strength, cognitive scores and hippocampal subfield volumes. Right hippocampal fissure partially mediated (20.33%) the relationship between right grip strength and ACE-III scores in males. Conclusions: Grip strength was correlated with hippocampal subfield integrity and cognitive function in a sex-specific manner. These observations illustrated an associative pathway linking muscular strength to cognitive vulnerability, with grip strength representing a potential observational marker for early-stage cognitive risk.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.