ArticleJournal of veterinary research2026
Impact of copper deficiency in cows on immune system function in offspring: a study using lymphocyte immunophenotyping.
Article in Journal of veterinary research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Copper (Cu) deficiency is a common, often subclinical problem in dairy cattle herds that can adversely affect haematopoietic processes and immune function. This study aimed to evaluate the effect of hypocupraemia in cows on selected haematological parameters and identify the immunophenotype of calf lymphocytes. Material and Methods: The study included Holstein-Friesian cows and their calves aged two to six weeks, which were divided into two groups: a hypocupraemic group (17 cows and 17 calves) and a normocupraemic group (18 cows and 18 calves). Haematological and biochemical analyses were performed, and lymphocyte subpopulations (CD4 Results: Cows with hypocupraemia exhibited reduced HGB and HCT values. Calves born to cows with Cu deficiency showed decreased erythrocyte indices, a reduced CD4 Conclusion: The obtained results indicate that even moderate copper deficiency in pregnant cows may negatively influence the haematological and immunological status of their offspring. These findings underline the necessity of systematic monitoring of copper status in dairy herds in order to prevent subclinical deficiencies and their long-term consequences for calf health and immunity.
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