Evidence map›Paper›PMID 42877328›Full record

ArticleRSC advances2026

Mixed-thiol functionalised gold nanoparticles for trastuzumab delivery: chemical interaction and photothermal therapeutic potential.

Tommaso A Salamone, Rosanna Mosetti, Annalisa D'Arco, Stefano Lupi, Francesca Petronella, Arianna Avitabile, Flaminia Pompeo, Luciano De Sio, Sofia Marotta, Stella Mrmić and 8 more

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Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Tommaso A SalamoneDepartment of Clinical and Molecular Medicine, Sapienza University of Rome Rome 00189 Italy.
Rosanna MosettiDepartment of Basic and Applied Sciences for Engineering, Sapienza University of Rome 00161 Rome Italy.
Annalisa D'ArcoDepartment of Physics, Sapienza University of Rome Rome 00185 Italy.
Stefano LupiDepartment of Physics, Sapienza University of Rome Rome 00185 Italy.
Francesca PetronellaNational Research Council, Department of Chemical Sciences and Materials Technologies, Institute of Crystallography Montelibretti 00010 Italy.
Arianna AvitabileDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Latina 04100 Italy.
Flaminia PompeoDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Latina 04100 Italy.
Luciano De SioDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Latina 04100 Italy.ORCID https://orcid.org/0000-0002-2183-6910
Sofia MarottaDepartment of Clinical and Molecular Medicine, Sapienza University of Rome Rome 00189 Italy.
Stella MrmićDepartment of Clinical and Molecular Medicine, Sapienza University of Rome Rome 00189 Italy.
Beatrice PennacchiDepartment of Chemistry, Sapienza University of Rome Rome 00185 Italy Tommaso.salamone@uniroma1.it ilaria.fratoddi@uniroma1.it.
Sara CerraDepartment of Chemistry, Sapienza University of Rome Rome 00185 Italy Tommaso.salamone@uniroma1.it ilaria.fratoddi@uniroma1.it.ORCID https://orcid.org/0000-0002-5549-9406
Souren GrigorianInstitute of Physics, University of Siegen Siegen D-57068 Germany.
Michael PaulusFakultät Physik/DELTA, Technische Universität Dortmund 44221 Dortmund Germany.
Maurizio AlimandiDepartment of Clinical and Molecular Medicine, Sapienza University of Rome Rome 00189 Italy.
Pankaj TrivediDepartment of Experimental Medicine, Sapienza University of Rome Rome 00161 Italy.
Eleni AnastasiadouDepartment of Clinical and Molecular Medicine, Sapienza University of Rome Rome 00189 Italy.
Ilaria FratoddiDepartment of Chemistry, Sapienza University of Rome Rome 00185 Italy Tommaso.salamone@uniroma1.it ilaria.fratoddi@uniroma1.it.ORCID https://orcid.org/0000-0002-5172-0636

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Small-sized gold nanoparticles (AuNPs) functionalised with hydrophilic thiols were investigated. Sodium 3-mercapto-1-sulfonate and 2-(diethylamino)ethanethiol hydrochloride were used as stabilising agents in a wet synthesis approach to provide a stable colloidal system. AuNPs were loaded with the antibody trastuzumab (TZ) to evaluate the potential use of the system for photothermal-assisted controlled drug release. Furthermore, to gain a deeper understanding of the chemical interactions occurring at the interface between TZ and the surface thiols of the nanoparticles, FT-IR studies were performed both in the solid state and in suspension, suggesting a strong interaction between the surface thiols and the amidic functional groups of TZ. The photothermal (PT) behaviour of the pristine AuNPs was investigated under continuous-wave laser irradiation at 532 nm, matching the plasmon resonance band of the gold nanoparticles, resulting in an up to 20 °C temperature increase. FT-IR measurements were also carried out after laser irradiation to evaluate the potential for a controlled release of TZ from the nanoparticle surface, suggesting that light irradiation can trigger the release of the drug from the AuNPs surface, with no detrimental effect from the temperature increase. Finally, SAXS studies enabled the investigation of TZ loading and release kinetics

Identifiers

PMID42877328
PMCPMC13667367

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.