Evidence map›Paper›PMID 42877311›Full record

ArticleJournal of Alzheimer's disease reports

Retinal thickness is associated with global cognition and executive function in mild cognitive impairment due to Alzheimer's disease.

Annahita Amireskandari, Camila Vieira Ligo Teixeira, Patrick Worhunsky, Cierra Keith, Joseph Malone, Melanie Ward, Marc W Haut, Tony Realini, Victor Finomore, Ali Rezai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Annahita AmireskandariDepartment of Ophthalmology and Visual Sciences, West Virginia University, Morgantown, WV, USA.ORCID https://orcid.org/0000-0002-9118-1622
Camila Vieira Ligo TeixeiraRockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA.ORCID https://orcid.org/0000-0002-9440-0907
Patrick WorhunskyRockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA.ORCID https://orcid.org/0000-0001-9629-1428
Cierra KeithRockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA.ORCID https://orcid.org/0000-0001-6607-4000
Joseph MaloneRockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA.
Melanie WardRockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA.
Marc W HautRockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA.
Tony RealiniDepartment of Ophthalmology and Visual Sciences, West Virginia University, Morgantown, WV, USA.
Victor FinomoreRockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA.
Ali RezaiRockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA.

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Laura F. Gibson · 2012 to 2026
$81.0M
NIGMS NIH HHS U54 GM104942
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a neurodegenerative disease that leads to cognitive impairment and dementia, and retinal imaging is being explored as a biomarker. We examined the differences in retinal thickness by optical coherence tomography (OCT) between 47 participants with mild cognitive impairment due to Alzheimer's disease (Aβ+MCI) and 23 age-matched controls, as well as associations between cognition and OCT. There was no significant difference in retinal thickness between groups. However, retinal measures were robustly associated with global cognition and executive function in those with Aβ+MCI. Further studies with larger samples are needed to understand the clinical utility of OCT in AD.

Indexed as

Alzheimer's diseasecognitionoptical coherence tomographyretina

Identifiers

PMID42877311
PMCPMC13662318

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.