Evidence map›Paper›PMID 42877303›Full record

ArticleJournal of Alzheimer's disease reports

Does depression in Alzheimer's disease show evidence of differential gene expression in neurons or microglia compared to Alzheimer's disease without depression?

Lindsey I Sinclair, Mizuki Morisaki, Peter P Henley, Emma L Dempster, Clive G Ballard, Jordan T Lin, Robert MacLachlan, Seth Love

Abstract read
In one paragraph

Article in Journal of Alzheimer's disease reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lindsey I SinclairCerebrovascular and Dementia Research Group, Bristol Medical School, University of Bristol, Southmead Hospital, Bristol, UK.ORCID https://orcid.org/0000-0002-4776-4118
Mizuki MorisakiCerebrovascular and Dementia Research Group, Bristol Medical School, University of Bristol, Southmead Hospital, Bristol, UK.
Peter P HenleyCerebrovascular and Dementia Research Group, Bristol Medical School, University of Bristol, Southmead Hospital, Bristol, UK.ORCID https://orcid.org/0000-0003-4905-482X
Emma L DempsterNIHR Exeter Biomedical Research Centre, University of Exeter Medical School, Exeter, UK.
Clive G BallardNIHR Exeter Biomedical Research Centre, University of Exeter Medical School, Exeter, UK.
Jordan T LinCerebrovascular and Dementia Research Group, Bristol Medical School, University of Bristol, Southmead Hospital, Bristol, UK.
Robert MacLachlanCerebrovascular and Dementia Research Group, Bristol Medical School, University of Bristol, Southmead Hospital, Bristol, UK.
Seth LoveCerebrovascular and Dementia Research Group, Bristol Medical School, University of Bristol, Southmead Hospital, Bristol, UK.

Funding

Wellcome Trust
6 · The paper itself

Abstract

Background: Depression in Alzheimer's disease (AD) is common, distressing, difficult to treat and inadequately understood. Objective: We compared gene expression in neurons and microglia from AD patients +/- depression, stratified according to depression polygenic risk score (PRS-D) and looked for differential pathway regulation. Methods: We identified AD patients with ( Results: After quality control, microarray data were available for AIns microglia ( Conclusions: In conclusion we have identified pathways that may contribute to the development of depression in AD. A majority were identified predominantly in microglia.

Indexed as

Alzheimer's diseasedepressiondepressive disordergene expression

Identifiers

PMID42877303
PMCPMC13662302

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.