ArticleFrontiers in pediatrics2026
Duration of surfactant administration and its impact on stabilisation of vital parameters in very preterm neonates <28 weeks of gestational age (SurfStab): 1 min versus 5 min-study protocol for a prospective randomised-controlled phase IV trial.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07261787 (Duration of Surfactant Administration and Impact on Stabilisation of Vital Parameters in Very Preterm Neonates), which is not on this map. Not yet cited in PubMed.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Duration of Surfactant Administration and Impact on Stabilisation of Vital Parameters in Very Preterm Neonates: 1 Minute Versus 5 Minutes - a Prospective Randomised-controlled Phase IV Trial - A Randomised Clinical Trial on Influence of Duration of Surfactant Administration on Stabilisation of Routine Monitoring Parameters and Cerebral Tissue Oxygen Saturation Monitoring in Preterm Neonates < 28 Weeks of Gestational Age
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6 authors.
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Abstract
Background: Respiratory distress syndrome remains one of the leading causes of morbidity and mortality in extremely preterm neonates. Surfactant replacement therapy substantially improves survival. Current European Consensus Guidelines recommend the less invasive surfactant administration (LISA) technique. However, no evidence exists on whether the duration of administration affects physiological stability. Rapid surfactant administration may provoke transient hypoxia or bradycardia due to airway obstruction, whereas slower delivery could potentially reduce such fluctuations. Methods/design: The SurfStab Trial is a single-centre, randomised, controlled phase IV clinical trial conducted at the Division of Neonatology, Medical University of Graz, Austria. Extremely preterm neonates (< 28 weeks of gestation) requiring surfactant via LISA will be randomly allocated (1:1) to receive surfactant administration over either 1 min ("1-min group") or 5 min ("5-min group"). The primary outcome is the maximum change in cerebral oxygen saturation (crSO Discussion: This trial will address a crucial gap in neonatal care by determining whether the duration of surfactant administration influences cerebral and systemic oxygen stability in extremely preterm neonates. The findings may refine evidence-based recommendations for optimal LISA procedure and may contribute to improved outcomes. Clinical Trial Registration: ClinicalTrials.gov, Identifier: NCT NCT07261787. Registered 02/12/2025. Eu CT number 2025-522754-39-00. Registered 01/12/2025.
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