ArticleFrontiers in aging neuroscience2026
Carotid atherosclerosis progression in patients with Parkinson's disease: a prospective cohort study.
Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Evidence regarding the association between Parkinson's disease (PD) and cardio-cerebrovascular risk remains conflicting, and it is unclear whether the dynamic progression of carotid atherosclerosis in PD patients differs from that in non-PD individuals. This study aimed to compare the progression of carotid atherosclerosis over a 1-year follow-up between PD patients and matched controls, and to investigate whether PD influences this progression independently of traditional cardiovascular risk factors. Methods: This prospective cohort study ultimately included 61 PD patients and 59 age- and sex-matched non-PD controls. Carotid ultrasound was performed at baseline and at the 1-year follow-up. The primary outcome was the annual change in total plaque area (ΔTPA), with plaque progression defined as ΔTPA ≥ 0.05 cm Results: At baseline, carotid intima-media thickness and TPA were significantly lower in the PD group than in the control group (both Conclusion: Carotid atherosclerosis progression is significantly slower in PD patients than in non-PD individuals, and this effect is independent of traditional cardiovascular risk factors. These findings suggest that PD patients may exhibit a "vascular protective phenotype," and that a unique shared regulatory network may exist between neurodegenerative processes and peripheral vascular homeostasis.
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