ArticleArchives of medical science : AMS2026
Serum γ-Klotho and fibroblast growth factor-2 levels in patients with pressure ulcers.
Article in Archives of medical science : AMS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Introduction: This study aimed to evaluate the serum levels of γ-Klotho and fibroblast growth factor 2 (FGF2) in patients with pressure ulcers. Material and methods: Patients aged ≥ 18 years receiving care from Home Health Care Services were included. The case group consisted of individuals with stage 2-4 pressure ulcers, while the control group comprised patients without ulcers, matched for age and sex. Sociodemographic characteristics, medical device usage, and nutritional status were assessed for all participants. In the case group, additional data regarding ulcer site, stage, number, and dimensions were collected. Serum levels of γ-Klotho and FGF2 were measured using ELISA. Results: A total of 80 participants were enrolled (40 (50.0%) in each group). The median FGF2 level was 220.8 [IQR 26.8] pg/ml in the case group and 219.1 [29.1] pg/ml in the control group ( Conclusions: Although serum levels did not differ between groups, the exclusive correlation between γ-Klotho and FGF2 in the pressure ulcer group suggests a potential association with chronic wound characteristics, warranting further investigation.
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