Evidence map›Paper›PMID 42877120›Full record

ArticleArchives of medical science : AMS2026

Association between the Dietary Index for Gut Microbiota and osteoporosis: a cross-sectional study from NHANES among individuals aged ≥ 50 years.

Zicong Liang, Jianwei Xu, Jingxia Xu, Ruina Lu

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Article in Archives of medical science : AMS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Zicong LiangDepartment of Basic Medicine, Qiannan Medical College for Nationalities, Duyun, China.
Jianwei XuCenter for Tissue Engineering and Stem Cell Research, Guizhou Medical University, Guiyang, China.
Jingxia XuDepartment of Gastroenterology, Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Ruina LuDepartment of Medical Ultrasonics, The People's Hospital of Qiannan, Qiannan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The gut microbiota serves as a critical interface between the host's internal environment and external factors, influencing bone mass and quality by modulating immune homeostasis, mineral absorption, and the production of systemically active metabolites. In this context, the Dietary Index for Gut Microbiota (DI-GM) provides a valuable metric for quantifying diet quality in relation to microbiota health. Therefore, investigating the association between DI-GM and the risk of osteoporosis (OP) is important for developing evidence-based dietary prevention guidelines. Material and methods: This cross-sectional study leveraged data from the U.S. National Health and Nutrition Examination Survey (NHANES) in 2005-2010 and 2013-2014. Multivariable weighted logistic regression (WLR) models were employed to ascertain the association between DI-GM and the prevalence of OP. Restricted cubic splines (RCS) were leveraged to explore the dose-response relationship between DI-GM and OP. Subgroup analyses and interaction tests were performed to validate the reliability of the findings. Results: Our analysis included 8,065 U.S. adults aged ≥ 50 years. The multivariable WLR analysis revealed that the risk of OP significantly decreased with increasing DI-GM scores (OR = 0.929, 95% CI: 0.874-0.988, Conclusions: Higher DI-GM scores were associated with lower risk of OP, indicating a protective role for diets that enhance GM diversity.

Indexed as

dietary interventiongut microbiota diversityNHANESnutritionosteoporosis

Identifiers

PMID42877120
PMCPMC13663671

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.