Evidence map›Paper›PMID 42877102›Full record

ReviewFrontiers in chemistry2026

Emerging NPR-B agonists for cartilage and bone: from CNP biology to translational compound design.

Yasuhiko Ago, Amali Karunathilaka, Jacky M Guerrero-Vargas, Shunji Tomatsu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yasuhiko AgoDepartment of Biomedical Research, Nemours Children's Health, Wilmington, DE, United States.
Amali KarunathilakaDepartment of Biomedical Research, Nemours Children's Health, Wilmington, DE, United States.
Jacky M Guerrero-VargasDepartment of Biomedical Research, Nemours Children's Health, Wilmington, DE, United States.
Shunji TomatsuDepartment of Biomedical Research, Nemours Children's Health, Wilmington, DE, United States.

Funding

Enhancement of Newborn Screening Diagnostic Paradigms to Improve the Efficacy of Treatment for Krabbe Disease, Pompe Disease, and Mucopolysaccharidosis Type 1R01HD104814 · NICHD · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Kabir Jalal, Daniel Woo · 2022 to 2026
$3.3M
Non-invasive functional assessment and pathogenesis of Morquio AR01HD102545 · NICHD · NEMOURS CHILDREN'S HOSPITAL, DELAWARE · PI TOMATSU, SHUNJI · 2021 to 2025
$2.9M
NICHD NIH HHS R01 HD102545NICHD NIH HHS R01 HD104814
6 · The paper itself

Abstract

Disorders affecting cartilage and bone development frequently originate from disrupted endochondral ossification within growth-plate cartilage. Nonetheless, few therapeutic interventions directly target the local signaling pathways governing this process. This review explores the C-type natriuretic peptide (CNP)/natriuretic peptide receptor B (NPR-B) axis as a mechanism-based therapeutic approach addressing issues in cartilage and bone, including skeletal dysplasias, genetic short-stature conditions, and acquired ailments such as bone fractures. It summarizes the production and processing of CNP

Indexed as

drug deliveryendochondral ossificationNPR-B agonistpeptide therapeuticsskeletal dysplasiatranslational medicine

Identifiers

PMID42877102
PMCPMC13663181

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.