ArticleFrontiers in cell and developmental biology2026
Quantitative lipidomics reveals Lipid perturbation of plasma apoptotic extracellular vesicles during physiological aging.
Article in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Aging is closely implicated in the pathogenesis of chronic diseases, degenerative conditions, and mortality, making it a core research focus in geroscience. As direct secretory products of apoptotic cells, apoptotic bodies can directly reflect the intensity of apoptotic activity and the degree of systemic and cellular aging. Given their close correlation with senescence progression, apoptotic bodies hold great potential as reliable and sensitive biomarkers for evaluating aging status. However, apoptotic bodies as effective indicators of aging remain to be explored. Methods: We characterized the lipid profile of apoptotic bodies (ApoEVs) and explored the changes in lipid species related to aging. Total lipids, multiple lipid subclasses, and fatty acid saturation within plasma apoptotic bodies were analyzed to identify aging-associated lipid alterations. Results and Discussion: A comprehensive reduction in total lipids, multiple lipid subclasses, and fatty acid saturation within plasma apoptotic bodies highlights systemic lipid reprogramming in aging. Decreased total levels of Hex2Cer, LPC, LPE, TG, ChE, SM, and SPH are the features of aging. This study not only deepens the understanding of aging-related lipid dysfunction, but also offers circulating lipid biomarkers for assessing biological aging and age-related pathologies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.