Evidence map›Paper›PMID 42877025›Full record

ArticleFrontiers in pediatrics2026

Prevalence and clinical significance of

Xiangxiang Xiao, Cuiyun Li, Tian'e Cai, Liting Chen, Xiaoyan Lin, Yuanyuan Wang, Guiyan Yang, Hui Wei, Wei Li, Ying Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiangxiang Xiao *Department of Medical Genetics and Antenatal Diagnosis Center, Hainan Branch, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Sanya, China.
Cuiyun Li *Department of Medical Genetics and Antenatal Diagnosis Center, Hainan Branch, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Sanya, China.
Tian'e CaiDepartment of Medical Genetics and Antenatal Diagnosis Center, Hainan Branch, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Sanya, China.
Liting ChenDepartment of Medical Genetics and Antenatal Diagnosis Center, Hainan Branch, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Sanya, China.
Xiaoyan LinDepartment of Medical Genetics and Antenatal Diagnosis Center, Hainan Branch, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Sanya, China.
Yuanyuan WangDepartment of Medical Genetics and Antenatal Diagnosis Center, Hainan Branch, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Sanya, China.
Guiyan YangDepartment of Medical Genetics and Antenatal Diagnosis Center, Hainan Branch, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Sanya, China.
Hui WeiDepartment of Medical Genetics and Antenatal Diagnosis Center, Hainan Branch, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Sanya, China.
Wei LiDepartment of Medical Genetics and Antenatal Diagnosis Center, Hainan Branch, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Sanya, China.
Ying YuDepartment of Medical Genetics and Antenatal Diagnosis Center, Hainan Branch, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Sanya, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Alpha-thalassemia is a common genetic disorder in southern China. The - Methods: A total of 474 reproductive-age individuals undergoing prenatal thalassemia screening were enrolled from February 2022 to April 2025. Peripheral blood samples were collected, and genetic testing was performed using next-generation sequencing, with multiplex ligation-dependent probe amplification (MLPA) and Sanger sequencing as supplements. Results: Among 474 subjects, 182 (38.40%) carried thalassemia mutations, including 149 (31.43%) with Discussion: This study is the first to report a high prevalence of the -

Indexed as

3.7 kb deletion α -thalassemiahematological phenotypethalassemia screening- α 3.7 IIIα +-thalassemia

Identifiers

PMID42877025
PMCPMC13661913

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.