Evidence map›Paper›PMID 42876979›Full record

ArticleFrontiers in aging neuroscience2026

Complement C4b and factor B in astrocyte-derived exosomes as novel biomarkers for amnestic mild cognitive impairment.

Yu Li, Menglu Zhang, Chao Ying, Chao Han, Qimeng Li, Yanning Cai

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In one paragraph

Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yu Li *Department of Neurobiology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Menglu Zhang *Department of Neurobiology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Chao YingSchool of Rehabilitation and Exercise Health, Gannan Medical University, Ganzhou, Jiangxi, China.
Chao HanNational Clinical Research Center for Geriatric Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China.
Qimeng LiBeijing Geriatric Medical Research Center, Beijing, China.
Yanning CaiDepartment of Neurobiology, Xuanwu Hospital, Capital Medical University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroinflammation represents a fundamental pathological mechanism underlying amnestic mild cognitive impairment (aMCI), with dysregulated activation of the complement system playing a pivotal role. Astrocyte-derived exosomes (ADEs), which are capable of traversing the blood-brain barrier (BBB), offer a non-invasive means to investigate central nervous system pathology. This study explored the diagnostic potential of two principal complement components, C4b and factor B (FB), within plasma-derived ADEs for aMCI and analyzed their interaction with the

Indexed as

amnestic mild cognitive impairmentApoE ε4astrocyte-derived exosomescomplement C4bcomplement factor B

Identifiers

PMID42876979
PMCPMC13661567

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.