ArticleFrontiers in pharmacology2026
Phenolic metabolites from
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Carob (Ceratonia siliqua L., Fabaceae) is a Mediterranean tree whose pods are rich in phenolic metabolites and are credited with antioxidant, anti-inflammatory,hypolipidemic and antimicrobial properties. Methods: The chemical composition of MECp was determined by high-performance liquid chromatography coupled with ultraviolet detection (HPLC/UV). Free radical-scavenging and ferric-reducing capacities were measured using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric-reducing antioxidant power (FRAP) analytical descriptors assays, and soybean LOX-1 inhibition was assessed in vitro and examined in silico by molecular docking against the enzyme (PDB ID: 3O8Y). Gallstones removed at surgery were confirmed as cholesterol stones by Fourier transform infrared spectroscopy with attenuated total reflectance (FTIR-ATR) and then incubated in MECp under continuous agitation for 4 weeks, with a sodium chloride solution (NaCl, 9 g/L) as control. Gallstone mass after drying at 40 °C, the percentage of gallstone-dissolving capacity (% GDC) and the pH of the medium were recorded weekly. Results: HPLC/UV analysis identified 20 phenolic metabolites in MECp. The extract contained 160.68 mg GAE/g DE of total phenolics and 9.19 mg QE/g DE of total flavonoids, with median inhibitory concentrations (IC50) of 0.16, 0.86 and 0.19 mg/mL for the DPPH, FRAP and soybean LOX-1 inhibition assays, respectively. Compared with the control, MECp produced a highly significant increase in % GDC over time, and the docking analysis revealed strong and stable interactions between the major polyphenols and the soybean LOX-1 active site. Discussion: The dissolution obtained with MECp is consistent with its phenolic composition, and the docking results agree with the soybean LOX-1 inhibition measured in vitro. These findings identify MECp as a promising natural candidate for cholesterol gallstone management and support further preclinical investigation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.