Evidence map›Paper›PMID 42876922›Full record

ArticleInternational journal of chronic obstructive pulmonary disease2026

The Prognostic Value of PaCO

Fanghong Song, Yadong Zhao, Chao Yu

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of chronic obstructive pulmonary disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Fanghong SongGraduate School, Dalian Medical University, Dalian, 116044, People's Republic of China.
Yadong ZhaoDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, 116011, People's Republic of China.
Chao YuDepartment of Respiratory and Critical Care Medicine, Yingkou Central Hospital, Yingkou, 115000, People's Republic of China.ORCID 0009-0001-5601-2823

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) complicated by Type II respiratory failure frequently requires noninvasive ventilation (NIV). However, 10-25% of patients fail NIV and require intubation. The optimal timing and threshold of partial pressure of arterial carbon dioxide (PaCO Methods: In this two-center retrospective cohort study of 676 patients with AECOPD and Type II respiratory failure treated with NIV between 2012 and 2025, we used multivariable logistic regression and restricted cubic spline (RCS) analysis (4 knots at the 5th, 35th, 65th, and 95th percentiles) to assess the dose-response relationship between 24-hour post-treatment PaCO Results: NIV failure occurred in 73 patients (10.8%). After full adjustment for age, heart rate, white blood cell count, hemoglobin, albumin, blood urea nitrogen, D-dimer, and baseline HACOR score, each 1 mmHg increase in 24h PaCO Conclusion: A 24-hour post-treatment PaCO

Indexed as

Carbon DioxideLungNoninvasive VentilationPulmonary Disease, Chronic ObstructiveRespiratory InsufficiencyAgedAged, 80 and overBiomarkersChinaDisease ProgressionFemaleHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisBiomarkersCarbon Dioxidehypercapniaintensive careNIV failurerestricted cubic spline

Identifiers

PMID42876922
PMCPMC13662540

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.