ArticleJournal of Alzheimer's disease reports
Herpes simplex virus,
Article in Journal of Alzheimer's disease reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Olfactory dysfunction (OD) is associated with neurodegenerative disorders, including Alzheimer's disease (AD). Herpes simplex virus type 1 (HSV1) may increase AD risk, but longitudinal changes in olfaction related to HSV1 carriage and apolipoprotein ε4 ( Objective: To investigate if OD is associated with carriage of HSV1, and whether Methods: From a large population-based cohort study in northern Sweden (Betula study), 1288 individuals with a baseline odor identification assessment were included, with follow-up assessment (n = 950) after five or ten years. Odor sensitivity (odor threshold test) was tested at a single time point for 651 individuals. HSV1 carriership and apolipoprotein E genotype were established for all participants. Results: Weighted linear mixed-model analyses showed that carriage of HSV1, regardless of Conclusions: HSV1 did not associate with OD in this population-based cohort study with 5-10 years of follow-up, where olfaction was measured and analyzed using two different objective measurements. The association between OD and neurodegenerative diseases needs further investigation.
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