Trial reportFrontiers in pharmacology2026
Four-week supplementation with a blackcurrant formulation enhances cognitive performance, reduces mental fatigue and modulates peripheral monoamine metabolism in older adults: a randomized, double-blind, placebo-controlled, crossover study.
Trial report in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Authors and funding
10 authors.
Funding
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Abstract
Introduction: Age-related cognitive decline is an increasing concern in older adults. While blackcurrants ( Methods: In this randomized, placebo-controlled, double-blinded crossover study of healthy older adults (62 ± 1 years), 26 of the 30 participants enrolled completed the study per protocol. Participants consumed either a placebo or a flavonoid-rich blackcurrant formula (BCF, 7.8 mg anthocyanins/kg body weight freeze-dried blackcurrant, 200 mg L-theanine, and 100 mg pine bark extract) in a beverage format daily for 4 weeks, with interventions separated by a two-week washout period. For each intervention, cognitive and mood outcomes were assessed following a single dose (acute) and after 4 weeks' supplementation. Platelet MAO-B activity, circulating neurotransmitter concentrations, and anthocyanin, L-theanine and sarmentosin bioavailability were measured from venous blood samples drawn at baseline, 1 h, 2.4 h and 4 wk after intervention supplementation. Results: A significant reduction in Rapid Visual Information Processing (RVIP) false alarms ( Conclusion: Findings from this study indicate that 4 weeks of BCF supplementation sustained attention in healthy older adults, extending evidence for BCF-related cognitive benefits across both younger and older populations. Clinical Trial Registration: https://anzctr.org.au/, identifier: ACTRN12621001590853.
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