SynthesisFrontiers in neurology2026
Impact of early goal-directed mobilization on ICU-acquired weakness: a meta-analysis.
Synthesis in Frontiers in neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: ICU-acquired weakness (ICU-AW) significantly impairs muscle strength and physical function in critically ill patients. Early mobilization interventions have been increasingly adopted, yet the specific effects of a structured EGDM program on ICU-AW and functional outcomes have not been systematically quantified. This meta-analysis aimed to evaluate the effects of EGDM on ICU-AW, muscle strength, and functional outcomes. Methods: PubMed, Web of Science, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang Data, and Viper Information Products (VIP) databases were searched for randomized controlled trials (RCTs) up to November 30, 2025. Two reviewers independently screened studies, extracted data, and assessed risk of bias using RoB 2.0. RevMan 5.4 was used for meta-analysis. Subgroup analysis was prespecified by allocation concealment. Results: Nine RCTs (907 patients) were included. EGDM reduced ICU-AW [ Conclusion: EGDM may improve muscle strength and physical function in ICU patients. The available evidence does not confirm a reduction in ICU-AW. The effects on ventilation duration and ICU stay varied substantially across studies, likely influenced by sedation protocols, weaning practices, and other context-specific factors. Further rigorous trials with detailed reporting of interventions and contextual factors are needed to guide precise clinical implementation. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420261280603, CRD420261280603.
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