ArticleFrontiers in aging neuroscience2026
Behavioral markers of motor reserve: stability, lateralization, and consistency.
Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07634055 (Assessment of Motor Reserve in the Preclinical Stages of Dementia.), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assessment of Motor Reserve in the Preclinical Stages of Dementia.
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13 authors.
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Abstract
Background: Motor reserve has been phenomenologically defined as the capacity to maintain motor performance despite aging-related or disease-related changes, but its objective kinematic basis remains insufficiently characterized. We operationalized motor reserve using measures from a sensor-equipped glove and tested whether they capture inter-individual differences beyond chronological aging. Methods: We enrolled 100 healthy adults (50 older and 50 younger) with a deliberately bimodal age distribution contrasting a young baseline with an older sample of interest. The glove recorded finger-level contact events during four tapping tasks (self-paced, maximum-velocity, synchronization to a 2-Hz metronome, and continuation after metronome withdrawal), each performed under right-hand, left-hand, and bilateral conditions. Motor reserve was assessed with the Motor Reserve Index questionnaire. Candidate kinematic indices were constructed to capture endogenous timing stability, externally paced velocity, bimanual coordination, touch-duration lateralization, and cross-context consistency (ClinicalTrials.gov database n° NCT07634055). Results: The central finding concerns which kinematic dimensions survive adjustment for chronological age. Aging affected a broad set of glove-derived parameters, most strongly under external pacing. After formal assessment of age confounding, three of the five candidate axes-endogenous timing stability, touch-duration lateralization, and cross-context consistency-retained an association with the Motor Reserve Index questionnaire (MRIq) independent of age, whereas externally paced velocity tracked age rather than reserve. A residual index (rMR) combining the three retained axes was associated with MRIq within the older group and predicted it out-of-sample (leave-one-out Conclusion: These findings provide initial evidence for a candidate kinematic index of motor reserve in healthy aging. Motor reserve was not reducible to global motor speed or chronological age but expressed as a multidimensional profile of timing stability, lateralized motor organization, and consistency across task contexts.
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