Evidence map›Paper›PMID 42876725›Full record

Trial reportFrontiers in nutrition2026

Correcting zinc deficiency in nursing home residents: a randomized trial comparing 30 and 60 mg/day elemental zinc supplementation.

Edwin F Ortega, Jonathan H Yao, Weimin Guo, Sarah K Boehm, Elizabeth Ergil, Dayong Wu, Simin N Meydani, Alexander Panda

Registry-linked trialAbstract readClinical Trial
In one paragraph

Trial report in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05527899 (Zinc Intervention in Elderly for Prevention of Pneumonia), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05527899 phase2 / phase3completednot on this map

Zinc Intervention in Elderly for Prevention of Pneumonia

TypeinterventionalSponsorTufts UniversityRan2022 to 2024Enrolled105ConditionsZinc DeficiencyArmsZinc gluconate
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Edwin F OrtegaNutritional Immunology Laboratory, JM USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, United States.
Jonathan H YaoNutritional Immunology Laboratory, JM USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, United States.
Weimin GuoNutritional Immunology Laboratory, JM USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, United States.
Sarah K BoehmNutritional Immunology Laboratory, JM USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, United States.
Elizabeth ErgilNutritional Immunology Laboratory, JM USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, United States.
Dayong WuNutritional Immunology Laboratory, JM USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, United States.
Simin N MeydaniNutritional Immunology Laboratory, JM USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, United States.
Alexander PandaNutritional Immunology Laboratory, JM USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, United States.

Funding

Zinc intervention in prevention of pneumonia in elderlyR34HL153277 · NHLBI · TUFTS UNIVERSITY BOSTON · PI PANDA, ALEXANDER · 2021 to 2022
$680k
NHLBI NIH HHS R34 HL153277
6 · The paper itself

Abstract

Introduction: Low serum zinc is associated with higher pneumonia incidence and illness duration compared to individuals with adequate serum zinc levels. However, the optimal and safe zinc supplementation dose to correct deficiency has not been established. This study aimed to determine the optimal and safe dose of elemental zinc supplementation to correct deficiency in older adults residing in nursing homes. Methods: Methods: We conducted a 12-month randomized, placebo-controlled, double-blind clinical trial in zinc-deficient nursing home residents, comparing supplementation of 30 and 60 mg/day elemental zinc versus placebo on zinc status and potential adverse effects (n = 26-35/group). Results: Both the 30 and 60 mg/day groups significantly increased serum zinc levels compared to placebo ( Discussion: In zinc deficient older adults, 60 mg/day of elemental zinc effectively corrected deficiency with no adverse effects. These findings inform the dosing protocol for a fully powered randomized trial testing the effect of zinc supplementation on pneumonia incidence and outcomes in this population. Clinical trial registration: https://clinicaltrials.gov/, identifier NCT05527899.

Indexed as

double-blind randomized controlled trialnursing home residentsolder adultszinc deficiencyzinc supplementation

Identifiers

PMID42876725
PMCPMC13661384

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.