SynthesisFrontiers in endocrinology2026
Research trends and knowledge structure of pancreatic cancer and type 2 diabetes mellitus research: a two-decade CiteSpace analysis.
Synthesis in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Pancreatic cancer and type 2 diabetes mellitus (T2DM) are closely linked through complex epidemiological and biological interactions. However, the development, knowledge structure, and research trends of this field have not been systematically characterized. This study aimed to investigate the research landscape and knowledge structure of pancreatic cancer and T2DM research from 2006 to 2025. Methods: We conducted the primary bibliometric analysis using WOSCC records, and separately analyzed PubMed-indexed clinical trials as a supplementary dataset. A total of 1,989 WOSCC publications were included in the bibliometric analysis, while 54 PubMed-indexed Clinical Trial records were included in the supplementary clinical trial assessment. CiteSpace was used to perform collaboration, co-citation, keyword, timeline, and burst analyses of the WOSCC dataset. Results: The number of publications increased steadily over the study period, particularly after 2015. The United States and China were the leading contributors, while the University of California System and Harvard University were among the most productive institutions. Major research themes included cancer risk, insulin resistance, metabolic inflammation, incretin-based therapies, and new-onset diabetes. Keyword evolution and burst analyses indicated increasing attention to mechanistic investigation, biomarker discovery, risk stratification, and precision medicine approaches. Conclusion: This study characterizes the development and knowledge structure of research on the relationship between pancreatic cancer and T2DM and highlights major research themes, emerging hotspots, and future directions for mechanistic investigation and clinical translation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.