Evidence map›Paper›PMID 42876627›Full record

ArticleFrontiers in cellular and infection microbiology2026

Histone demethylase JMJD2D promotes macrophage IL-12b expression and contributes to host defense against

Yilin Hong, Hanshi Guo, Bei Li, Jing Jin, Yang Zhao, Junjie Zhang, Jingna Yuan, Xiaochun Xia, Chundong Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yilin Hong *Xiamen Key Laboratory of Traditional Chinese Medicine Bio-engineering, School of Pharmacy, Xiamen Medical College, Xiamen, Fujian, China.
Hanshi Guo *State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian, China.
Bei Li *Ordos Center for Disease Control and Prevention, Ordos, China.
Jing JinState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian, China.
Yang ZhaoState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian, China.
Junjie ZhangState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian, China.
Jingna YuanState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian, China.
Xiaochun XiaDepartment of Public Health and Medical Technology, Xiamen Medical College, Xiamen, Fujian, China.
Chundong YuState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Methods: JMJD2D-deficient mice and wild-type littermates were infected with Results: JMJD2D deficiency markedly increased host susceptibility to Discussion: These findings identify JMJD2D as an epigenetic regulator of macrophage IL-12b expression and IL-12p70 production, and support its involvement in coordinated macrophage and CD8

Indexed as

Interleukin-12 Subunit p40Jumonji Domain-Containing Histone DemethylasesListeria monocytogenesListeriosisMacrophagesAnimalsDisease Models, AnimalHost-Pathogen InteractionsImmunity, InnateInnate Immunity RecognitionMiceMice, Inbred C57BLMice, KnockoutNod2 Signaling Adaptor ProteinInterleukin-12 Subunit p40Jumonji Domain-Containing Histone DemethylasesKdm6b protein, mouseNod2 protein, mouseNod2 Signaling Adaptor Proteinhistone demethylationIFNγIL-12binnate and adaptive immunityJMJD2DListeria monocytogenes

Identifiers

PMID42876627
PMCPMC13661335

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.