ArticleFrontiers in neurology2026
Increased visual reliance for postural control in multiple sclerosis: preliminary evidence from task-related cortical desynchronization.
Article in Frontiers in neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Balance impairment is one of the most disabling symptoms in multiple sclerosis (MS), yet the underlying cortical mechanisms remain poorly understood. This exploratory study investigated how postural demands modulate brain activity in MS. Methods: Seven individuals with MS (mean age: 51.1 ± 9.7 years; 5 women; median Expanded Disability Status Scale: 5.5, IQR: 4.5-6.0) and seven age- and sex-matched healthy controls (mean age: 51.0 ± 9.6 years) performed three static balance tasks on a force plate: quiet stance with eyes open, quiet stance with eyes closed, and narrow stance with eyes open. Electroencephalography (EEG) and center of pressure (COP) were simultaneously recorded. Group differences were assessed using Linear Mixed Models. Significant effects are reported with false discovery rate (FDR)-corrected Results: MS patients demonstrated greater postural sway than healthy controls, with FDR-corrected group × condition interactions across COP parameters (semi-partial Conclusion: These preliminary findings are consistent with an increased reliance on visual information for postural control in MS, accompanied by a task-related cortical desynchronization specifically upon visual deprivation. The observed effect sizes, while likely subject to inflation given the small sample size, suggest that oscillatory EEG parameters warrant investigation in larger confirmatory studies.
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