ReviewAging cell2026
Skeletal Muscle-Derived Extracellular Vesicles in Interorgan Communication During Aging.
Review in Aging cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Skeletal muscle is increasingly recognized as a secretory organ that communicates with distant tissues through the release of bioactive factors, including extracellular vesicles (EVs). During aging, muscle-derived EVs have emerged as important mediators of interorgan communication, influencing tissue homeostasis, regeneration, metabolism, and disease progression. Recent studies demonstrate that skeletal muscle EVs carry diverse cargos such as proteins, lipids, metabolites, and regulatory RNAs that can modulate the function of recipient cells in multiple organs. In particular, aging-associated alterations in EV biogenesis, cargo composition, and secretion may contribute to chronic inflammation, stem cell dysfunction, metabolic decline, and age-related pathologies. In this review, we summarize current advances in skeletal muscle-derived EV biology and their roles in interorgan communication during aging. We discuss mechanisms regulating EV formation and cargo loading, their impact on stem cell function and tissue regeneration, and their involvement in aging-related diseases. We also highlight the translational potential of muscle EVs as biomarkers and therapeutic targets. Together, these findings identify muscle-derived EVs as key regulators of systemic aging and interorgan signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.