Evidence map›Paper›PMID 42876090›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Enteric ChAT-Expressing Neurons Mediate the Protective Effect of Lactobacillus plantarum in Inflammatory Bowel Disease.

Bing Xia, Yuwei Sun, Jialin Wang, Yike Liu, Lu Wang, Shiqi Jiang, Gaiyan Bai, Ruijing Zhang, Yu Zhang, Rongwei Kou and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Bing XiaCollege of Food Science and Engineering, Northwest A&F University, Yangling, China.
Yuwei SunCollege of Food Science and Engineering, Northwest A&F University, Yangling, China.
Jialin WangCollege of Food Science and Engineering, Northwest A&F University, Yangling, China.
Yike LiuCollege of Food Science and Engineering, Northwest A&F University, Yangling, China.
Lu WangCollege of Food Science and Engineering, Northwest A&F University, Yangling, China.
Shiqi JiangCollege of Food Science and Engineering, Northwest A&F University, Yangling, China.
Gaiyan BaiDepartment of Gastroenterology, Shaanxi Provincial People's Hospital, Xi'an, China.
Ruijing ZhangCollege of Food Science and Engineering, Northwest A&F University, Yangling, China.
Yu ZhangDepartment of Gastroenterology, Shaanxi Provincial People's Hospital, Xi'an, China.
Rongwei KouState Key Laboratory of Eco-Hydraulics in Northwest Arid Region of China, School of Water Resources and Hydro-Electric Engineering, Xi'an University of Technology, Xi'an, China.
Danna WangCollege of Food Science and Engineering, Northwest A&F University, Yangling, China.
Beita ZhaoCollege of Food Science and Engineering, Northwest A&F University, Yangling, China.
Junjie YiFaculty of Food Science and Engineering, Yunnan Institute of Food Safety, Kunming University of Science and Technology, Kunming, China.ORCID https://orcid.org/0000-0002-5178-8817
Yu FuInstitute of Molecular and Cell Biology (IMCB), Agency for Science Technology and Research (A*STAR), Singapore.
Xiaoning LiuCollege of Food Science and Engineering, Northwest A&F University, Yangling, China.ORCID https://orcid.org/0009-0007-4060-1213
Xuebo LiuCollege of Food Science and Engineering, Northwest A&F University, Yangling, China.

Funding

National Natural Science Foundation of China 32472354National Natural Science Foundation of China 32603357Shaanxi Provincial Natural Science Basic Research Program 2024JC-YBQN-0094
6 · The paper itself

Abstract

The gut microbiota plays a crucial role in inflammatory bowel diseases (IBD), yet how specific microbial components influence disease progression remains incompletely understood. Our study reveals that decreased abundance of Lactobacillus species correlates with ulcerative colitis severity in patients. Among tested strains, L. plantarum A736, isolated from traditional fermented foods, demonstrated protective effects in ameliorating dextran sulfate sodium (DSS)-induced colitis in a mouse model. Strikingly, multi-omics analysis revealed that L. plantarum A736 uniquely enhances choline acetyltransferase-expressing (ChAT

Indexed as

ChAT‐expressing neuronsenteric nervous systemindole‐3‐lactic acidinflammatory bowel diseaseLactobacillus plantarumneuroimmune regulation

Identifiers

PMID42876090
PMCPMC13669556

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.