Evidence map›Paper›PMID 42875996›Full record

ArticleBrain and behavior2026

Naoxueshu Oral Liquid Attenuates Early Radiation-Induced Brain Injury in Rats.

Fuguang Li, Xiaolong Qu, Kuiyuan Li, Guosong Li, Shifang Zhou, Min Zhao, Chunyu Zhang, Lei Hui, Wenchao Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fuguang Li *Department of Neurosurgery, The First Affiliated Hospital of Henan Medical University; Henan medical Key Laboratory of Neurology, Henan Joint International Laboratory of Neurorestoratology for Senile Dementia, Henan Engineering Technology Research Center of Neurorestoratology ,Henan Engineering Laboratory of Neurorestoratology,Henan Key Laboratory of Neurorestoratology and Protein modification, First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, 453100, China., Xinxiang City, China.
Xiaolong Qu *Department of Neurosurgery, The First Affiliated Hospital of Henan Medical University; Henan medical Key Laboratory of Neurology, Henan Joint International Laboratory of Neurorestoratology for Senile Dementia, Henan Engineering Technology Research Center of Neurorestoratology ,Henan Engineering Laboratory of Neurorestoratology,Henan Key Laboratory of Neurorestoratology and Protein modification, First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, 453100, China., Xinxiang City, China.
Kuiyuan LiDepartment of Neurosurgery, The First Affiliated Hospital of Henan Medical University; Henan medical Key Laboratory of Neurology, Henan Joint International Laboratory of Neurorestoratology for Senile Dementia, Henan Engineering Technology Research Center of Neurorestoratology ,Henan Engineering Laboratory of Neurorestoratology,Henan Key Laboratory of Neurorestoratology and Protein modification, First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, 453100, China., Xinxiang City, China.
Guosong LiDepartment of Neurosurgery, The First Affiliated Hospital of Henan Medical University; Henan medical Key Laboratory of Neurology, Henan Joint International Laboratory of Neurorestoratology for Senile Dementia, Henan Engineering Technology Research Center of Neurorestoratology ,Henan Engineering Laboratory of Neurorestoratology,Henan Key Laboratory of Neurorestoratology and Protein modification, First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, 453100, China., Xinxiang City, China.
Shifang ZhouDepartment of Neurosurgery, The First Affiliated Hospital of Henan Medical University; Henan medical Key Laboratory of Neurology, Henan Joint International Laboratory of Neurorestoratology for Senile Dementia, Henan Engineering Technology Research Center of Neurorestoratology ,Henan Engineering Laboratory of Neurorestoratology,Henan Key Laboratory of Neurorestoratology and Protein modification, First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, 453100, China., Xinxiang City, China.
Min ZhaoDepartment of Neurosurgery, The First Affiliated Hospital of Henan Medical University; Henan medical Key Laboratory of Neurology, Henan Joint International Laboratory of Neurorestoratology for Senile Dementia, Henan Engineering Technology Research Center of Neurorestoratology ,Henan Engineering Laboratory of Neurorestoratology,Henan Key Laboratory of Neurorestoratology and Protein modification, First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, 453100, China., Xinxiang City, China.
Chunyu ZhangDepartment of Neurosurgery, The First Affiliated Hospital of Henan Medical University; Henan medical Key Laboratory of Neurology, Henan Joint International Laboratory of Neurorestoratology for Senile Dementia, Henan Engineering Technology Research Center of Neurorestoratology ,Henan Engineering Laboratory of Neurorestoratology,Henan Key Laboratory of Neurorestoratology and Protein modification, First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, 453100, China., Xinxiang City, China.
Lei HuiDepartment of Neurosurgery, The First Affiliated Hospital of Henan Medical University; Henan medical Key Laboratory of Neurology, Henan Joint International Laboratory of Neurorestoratology for Senile Dementia, Henan Engineering Technology Research Center of Neurorestoratology ,Henan Engineering Laboratory of Neurorestoratology,Henan Key Laboratory of Neurorestoratology and Protein modification, First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, 453100, China., Xinxiang City, China.
Wenchao LiDepartment of Neurosurgery, The First Affiliated Hospital of Henan Medical University; Henan medical Key Laboratory of Neurology, Henan Joint International Laboratory of Neurorestoratology for Senile Dementia, Henan Engineering Technology Research Center of Neurorestoratology ,Henan Engineering Laboratory of Neurorestoratology,Henan Key Laboratory of Neurorestoratology and Protein modification, First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, 453100, China., Xinxiang City, China.

Funding

Medical Science and Technology Research and Development Program of Henan Province LHGJ20240486
6 · The paper itself

Abstract

objectiveTo investigate the effect of Naoxueshu Oral Liquid on rats with radiation-induced brain injury.

methodsA total of 108 male Sprague-Dawley rats were randomly assigned to a control group, an irradiated + normal saline group (RBI+NS), and an irradiated + Naoxueshu Oral Liquid group (RBI+NXS). A radiation-induced brain injury model was established by single-dose whole-brain high-energy X-ray irradiation (30 Gy). After irradiation, rats received Naoxueshu Oral Liquid (0.5 mL/100 g/day, gavage) or normal saline for 14 days. Body weight was monitored, cerebral edema was assessed by brain tissue water content on Days 3, 7, and 14, histopathology was evaluated by hematoxylin-eosin (H&E) staining, and Morris water maze training was conducted from Day 8 to Day 13 post-irradiation, followed by the probe trial on Day 14 post-irradiation.

resultsBody weight differed significantly among groups after irradiation (Day 3/6/9/12: all p < 0.01). Specifically, at Day 12, body weight was 328.17±20.10 g (control), 258.50±18.87 g (RBI+NS), and 302.83 ± 10.87 g (RBI+NXS); RBI+NXS was higher than RBI+NS (p < 0.01), while control versus RBI+NS remained different (p < 0.01). H&E staining showed widened perineuronal and perivascular spaces after irradiation, which were attenuated by Naoxueshu. In the Morris water maze, RBI+NS rats exhibited prolonged latency and fewer platform crossings; these impairments were improved after Naoxueshu treatment.

conclusionNaoxueshu Oral Liquid reduced cerebral edema and improved Morris water maze performance in rats after whole-brain irradiation. Because behavioral outcomes were assessed only using the Morris water maze, the cognitive-related findings should be interpreted cautiously.

Indexed as

Brain EdemaBrain InjuriesDrugs, Chinese HerbalRadiation Injuries, ExperimentalAnimalsBrainMaleMaze LearningRatsRats, Sprague-DawleyDrugs, Chinese Herbalbrain edemabrain injuriescognitive impairmentNaoxueshu Oral Liquidradiation injuries

Identifiers

PMID42875996
PMCPMC13669539

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