ArticleAnimal genetics2026
Genome-Wide Characterization of Heterozygosity-Rich Regions in Kazakh Native Sheep Breeds.
Article in Animal genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Heterozygosity-rich regions (HRR) are genomic segments characterized by high heterozygosity that may arise from admixture, introgression, or balancing selection and may harbor loci associated with adaptation and fitness-related traits. This study aimed to characterize HRR patterns in five Kazakh sheep breeds using a publicly available OvineSNP50 genotyping dataset. After quality control, ~25 000 SNPs were retained for 1634 Akzhaiyk, 1089 Edilbay, 532 Kazakh Fine-Wool, 932 Kazakh Semi-Coarse, and 282 Saryarka sheep. HRR were detected separately in each breed using the sliding-window approach in detectRUNS R package, with a minimum segment length of 250 kb, at least 10 SNPs per window and segment, and a maximum of two opposing homozygous and one missing SNP per window. The average number of HRR per individual ranged from 40.75 ± 6.38 in Saryarka to 54.75 ± 7.34 in Kazakh Fine-Wool sheep. HRR lengths ranged from 259.07 kb to 3.26 Mb, with an average of 0.7 Mb across breeds. Seventeen HRR islands, defined as regions shared by HRR in at least 25% of individuals within a breed, were identified, including regions on chromosomes 8 and 17 shared across all breeds. Genes overlapping these islands were associated with cellular homeostasis, immunity, metabolism, growth, and stress response, while the HRR islands overlapped with QTL associated with health, wool characteristics, and reproduction. These findings highlight the potential of HRR analysis to identify candidate genomic regions relevant to adaptation and economically important traits, providing insights for the conservation and genetic improvement of Kazakh sheep populations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.