ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Mitochondria-Targeting Iron-Carbon Nanozymes Combat Hepatic Ischemia-Reperfusion Injury via the Dual Mechanisms of Respiratory Chain Remodeling and Pyroptosis Inhibition With MRI Monitoring.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
13 authors.
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Abstract
Hepatic ischemia‒reperfusion injury (HIRI) critically compromises liver surgery and transplantation outcomes. Its pathogenesis centers on mitochondrial dysfunction-driven oxidative stress and sterile inflammation. However, current therapies lack lesion-specific targeting, fail to suppress ROS generation at the mitochondrial source, and lack integrated theranostic capabilities such as cascade antioxidant activity, anti-inflammatory effects, and real-time imaging. To address these limitations, we developed FeCD-SS31, an integrated nanoplatform composed of a mesoporous Fe
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