Trial reportBMC musculoskeletal disorders2026
Factors associated with 1-year health-related quality of life after neck-specific exercise in chronic whiplash-associated disorders: an exploratory secondary analysis of a randomized controlled trial.
Trial report in BMC musculoskeletal disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03022812 (Is E-health a Way to Increase Ability and Health and Make Health Care More Effective in Chronic Whiplash? A Prospective Randomized Controlled Multicenter Trial), which is not on this map. Not yet cited in PubMed.
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The trial behind it
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Is E-health a Way to Increase Ability and Health and Make Health Care More Effective in Chronic Whiplash? A Prospective Randomized Controlled Multicenter Trial
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3 authors.
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Abstract
backgroundFactors associated with changes in health-related quality of life (HRQoL) outcomes in neck disorders have not been investigated after internet-based support for exercise. The purpose of the study was to investigate baseline and short-term outcome factors associated with changes in HRQoL (EQ-5D-3L and EQ-VAS) at 3 and 15 months, respectively, after a neck-specific exercise programme (NSE) for individuals with chronic whiplash-associated disorders grades 2 and 3.
methodsThis was a secondary analysis of a prospective randomized controlled multi-centre trial with concealed allocation. Participants (n = 140) were randomized to NSE at a physiotherapy clinic or internet-based NSE with four physiotherapy visits (NSEIT). Assessor-blinded investigators obtained measurements at baseline and at 3- and 15-month follow-up. Orthogonal partial least square (OPLS) and OPLS discriminant statistical analyses (OPLS-DA) were used.
resultsThere were no significant differences between the exercise programmes. Improvement in psychosocial measures, pain, disability and several objective measures were associated with improvements in HRQoL in OPLS models (R
conclusionsSeveral factors, including adverse psychosocial measures, may be clinically relevant for HRQoL after neck-specific exercise interventions. Given the models' weak predictive ability, the findings should be regarded as exploratory and hypothesis-generating.
trial registrationThe study was registered before data collection started, ClinicalTrials.gov Protocol ID: NCT03022812, initial release 12/20/2016. The study was approved by the regional ethical review board in Linköping, Sweden (Dnr 2016/135-31; 2016/526-32; 2017/45-32).
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