ArticleBasic and clinical andrology2026
Alterations in urinary microbiota composition and function in men with Asthenozoospermia: a case-control study.
Article in Basic and clinical andrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAsthenozoospermia (AZS) is a leading cause of male-factor infertility, yet the contribution of the urinary microbiota to sperm motility remains poorly defined, because previous work has focused almost exclusively on the seminal and gut microbiota. Here we used 16S rRNA gene sequencing to characterize the composition and functional profiles of the urinary microbiota in men with AZS and in fertile controls.
resultsIsolated AZS and age-matched fertile controls were enrolled, and urinary specimens from participants were sequenced successfully. Alpha diversity of the urinary microbiota did not differ between the two groups. In contrast, beta diversity analysis revealed a statistically significant difference in overall community structure, although the group effect was modest in magnitude (PERMANOVA on Bray-Curtis dissimilarities, R
conclusionsIt appears that men with AZS exhibit altered urinary microbiota structure and predicted functional profile. These associations extend the microbiome-male-infertility axis beyond the seminal and gut compartments and may inform biomarker discovery and microbiome-modulating strategies, although longitudinal and mechanistic studies are required to establish causality.
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