Evidence map›Paper›PMID 42875648›Full record

SynthesisCurrent pain and headache reports2026

Peripheral Nerve Stimulation for Essential Tremor: a Systematic Review and Meta-Analysis of Effectiveness and Safety.

Mohamed El-Moslemani, Abdallah Abbas, Haneen Sabet, Abdullah Almarfadi, Mohammad Mahadin, Ro'ya Khanfar, Obai Yousef, Amna Hussein, Alaa Abd-Elsayed, Julie G Pilitsis

Abstract readSystematic ReviewMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in Current pain and headache reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mohamed El-MoslemaniFaculty of Medicine, Al-Azhar University, Damietta, Egypt.
Abdallah AbbasFaculty of Medicine, Al-Azhar University, Damietta, Egypt.
Haneen SabetFaculty of Medicine, South Valley University, Qena, Egypt.
Abdullah AlmarfadiDepartment of Medicine, Ferhat Abbas University of Setif, Setif, Algeria.
Mohammad MahadinDepartment of Pathology and Microbiology, Jordan University of Science and Technology, Irbid, Jordan.
Ro'ya KhanfarDepartment of Medicine, Faculty of Medicine and Allied Medical Sciences, An-Najah National University, Nablus, 44839, Palestine.
Obai YousefDepartment of Neurosurgery, Tishreen University Hospital, Latakia, Syria.
Amna HusseinDepartment of Neurological Surgery, Houston Methodist Hospital, Houston, TX, USA.
Alaa Abd-ElsayedDepartment of Anesthesiology and Pain Management, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA. abdelsayed@wisc.edu.
Julie G PilitsisDepartment of Neurosurgery, University of Arizona College of Medicine, Tucson, AZ, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEssential tremor (ET) is the most prevalent movement disorder worldwide. There are limited current pharmacological therapies, and their side effects often preclude adequate doses. Surgical therapies, such as Deep Brain Stimulation (DBS) and Focused Ultrasound (FUS), are reserved for patients with tremor that debilitates activities of daily living (ADLs). Peripheral nerve stimulation (PNS), including transcutaneous afferent patterned stimulation (TAPS) and transcutaneous peripheral nerve stimulation (TPNS), has emerged as a promising non-invasive neuromodulatory approach for many patients with intermediate symptoms.

methodsA systematic review and meta-analysis following PRISMA 2020 guidelines was conducted, with searches across PubMed, Scopus, Cochrane, and Web of Science. Studies enrolling patients with ET assessing TAPS and TPNS were included. Primary outcomes were tremor severity (TETRAS performance scale, total TETRAS) and tremor amplitude. Secondary outcomes included functional disability (BF-ADL, TETRAS-mADL) and safety.

resultsNineteen studies (2,541 patients) were included. Sham-controlled analyses showed statistically significant improvement in TETRAS performance scale scores (MD = - 1.00; p = 0.002; I

conclusionsPNS consistently improved functional outcomes with a favorable safety profile in ET patients. These findings support PNS as a viable adjunctive or on-demand non-invasive therapeutic option, particularly for medication-refractory patients or those unsuitable for surgery.

Indexed as

Essential TremorPeripheral NervesTranscutaneous Electric Nerve StimulationActivities of Daily LivingHumansTreatment OutcomeEssential tremorMeta-AnalysisNeuromodulationPeripheral nerve stimulationSystematic reviewTranscutaneous afferent patterned stimulationTremor severity

Identifiers

PMID42875648

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.