ArticleInflammopharmacology2026
Evaluation of the anti-inflammatory potentials of ethanol leaf extract of Vigna unguiculata in Wistar rats.
Article in Inflammopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundInflammation involves complex biological pathways, notably characterized by the overexpression of cytokines such as IL-1β, TNF-α, IL-6, IL-8, and COX-2. Inflammation is the onset of many diseases and its control will prevent several progression and complications of many diseases.This study investigates the anti-inflammatory activity of ethanol leaf extract of Vigna unguiculata in rat models, with emphasis on its effects on serum inflammatory cytokines and acute-phase reactants.
methodsEthanol extract of Vigna unguiculata leaves was prepared and evaluated for anti-inflammatory activity using carrageenan-induced paw edema and egg albumin-induced paw inflammation models in Wistar rats. Serum levels of IL-1β, TNF-α, IL-6, IL-8, IL-10, IL-13, IFN-γ, CRP, and COX-2 were quantified using ELISA after treatment with extract doses of 100, 200, and 400 mg/kg. Indomethacin (10 mg/kg) served as the standard control. Phytochemical screening and acute toxicity testing were performed.
resultsThe extract significantly inhibited paw edema in a dose-dependent manner, with 400 mg/kg showing a 63.2% inhibition at 4 h post-carrageenan injection. Biomarker analysis showed significant decrease of pro-inflammatory cytokines (IL-1β, TNF-α, IL-6, IL-8, IFN-γ, CRP, and COX-2) and increase of anti-inflammatory cytokines (IL-10 and IL-13) (p < 0.05 vs. control). No signs of toxicity were observed up to 2000 mg/kg.
conclusionThe anti-inflammatory activity of Vigna unguiculata may be attributed to its modulatory effects on cytokines and acute-phase reactants. This validates its traditional use and suggests potential therapeutic benefits in inflammatory diseases.
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