Evidence map›Paper›PMID 42875633›Full record

ArticleSurgical endoscopy2026

EAES-SAGES clinical practice guideline update: multi-society recommendations on key controversies in the management of diverticular disease.

Bright Huo, Maher Al Khaldi, Dena Shehata, Elisa C Calabrese, Caroline Reinke, Francesco Carrano, Stephanie Breukink, Andreas M Kaiser, James Kimble, Nicole Buchenholz and 25 more

Abstract read
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In one paragraph

Article in Surgical endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

Bright HuoDivision of General Surgery, Department of Surgery, McMaster University, Hamilton, ON, Canada. brighthuo@dal.ca.ORCID http://orcid.org/0000-0003-4999-4328
Maher Al KhaldiDepartment of Colon and Rectal Surgery, Ellen Leifer Shulman and Steven Shulman Digestive Disease Center, Cleveland Clinic Florida, Weston, FL, USA.
Dena ShehataDepartment of Surgery, Lahey Hospital and Medical Center, Burlington, MA, USA.
Elisa C CalabreseDepartment of Surgery, University of California-East Bay, Oakland, CA, USA.
Caroline ReinkeWake Forest School of Medicine, Department of Surgery, Carolinas Medical Center, Atrium Health, Charlotte, NC, USA.
Francesco CarranoDivision of General and Emergency Surgery, Sant' Andrea Hospital, Department of Medical and Surgical Sciences and Translational Medicine, Faculty of Medicine and Psychology, Sapienza University, Rome, Italy.
Stephanie BreukinkDepartment of Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands.
Andreas M KaiserDivision of Colorectal Surgery, City of Hope National Medical Center, Duarte, CA, USA.
James KimblePatient Partner, New York, NY, USA.
Nicole BuchenholzPatient Partner, New York, NY, USA.
Irene MarafiniPoliclinico Tor Vergata, UOC Gastroenterologia, Rome, Italy.
Walter BifflDepartment of Surgery, Scripps Clinic/Scripps Clinic Medical Group, La Jolla, CA, USA.
Fausto CatenaDepartment of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
Frank FrizelleDepartment of Surgery and Critical Care, University of Otago, Christchurch, New Zealand.
Triantafyllos DouliasDepartment of Colorectal Surgery, Colchester Hospital, East Suffolk and North Essex NHS Foundation Trust, Colchester, UK.
Antonio TursiTerritorial Gastroenterology Service, Barletta-Andria-Trani (BAT) Local Health Agency, Andria, Italy.
Sophie MillerPatient Partner, New York, NY, USA.
Iro NtagaDepartment of Primary Education, University of Ioannina, Ioannina, Greece.
Justin DouradoDepartment of Colon and Rectal Surgery, Ellen Leifer Shulman and Steven Shulman Digestive Disease Center, Cleveland Clinic Florida, Weston, FL, USA.
Joe BroderickDepartment of Surgery, Brooke Army Medical Center, Fort Sam Houston, TX, USA.
Gita LingamSt. Mark's National Bowel Hospital, London, UK.
Anse de SadeleerDepartment of Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands.
Elizabeth BarberaDepartment of Surgery, RAF Lakenheath Hospital, Brandon, UK.
Xiaomei YaoDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Gordon GuyattDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Marina YiasemidouDepartment of Colorectal Surgery, The Royal London Hospital, Barts Health NHS Trust, London, UK.
Danique HeuvelingsDepartment of Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands.
Richard GarfinkleDivision of Colon and Rectal Surgery, Jewish General Hospital, Montreal, QC, Canada.
Maria Abou-KhalilDivision of General Surgery, Hôpital Maisonneuve-Rosemont, Montreal, QC, Canada.
Bethany J SlaterDepartment of Surgery, Mount Sinai Kravis Children's Hospital, New York, NY, USA.
Stavros A AntoniouDepartment of Surgery, Papageorgiou General Hospital, Thessaloniki, Greece.
Nicole BouvyNUTRIM, Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands.
Patricia SyllaDivision of Colon and Rectal Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Nader FrancisThe Griffin Institute, Northwick Park and St Mark's Hospital, Harrow, UK.
Marylise BoutrosDepartment of Colon and Rectal Surgery, Ellen Leifer Shulman and Steven Shulman Digestive Disease Center, Cleveland Clinic Florida, Weston, FL, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe identified areas of controversy in the management of patients with diverticular disease to develop key questions addressing the management of symptomatic uncomplicated diverticular disease (SUDD), uncomplicated diverticulitis, and complicated diverticulitis.

methodsWe performed a systematic review to identify randomized trials and cohort studies addressing our key questions. Informed by an updated evidence synthesis, an international, multidisciplinary panel of gastrointestinal surgeons, gastroenterologists, patient partners, and methodologists applied the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) evidence-to-decision framework during panel consensus meetings to derive recommendations for the management of patients with diverticular disease.

resultsThe systematic review identified 27 studies representing very low to moderate certainty evidence. The panel made the following recommendations: 1. In patients with SUDD, we suggest rifaximin or mesalamine over standard supportive care (conditional recommendation); 2. In patients with uncomplicated diverticulitis, we suggest no routine antibiotics (conditional recommendation); 3. In patients with persistent symptoms following an episode of recurrent uncomplicated diverticulitis, we suggest elective resection over observation (conditional recommendation); 4. In patients who have recovered from a first episode of uncomplicated diverticulitis, we suggest no routine follow-up colonoscopy (conditional recommendation); 5. In patients who have recovered from a first episode of diverticulitis complicated by an abscess, we suggest elective resection over surveillance (conditional recommendation). The panel judged that a significant proportion of patients would place a high value in reducing the risk of recurrence at 1 year but also acknowledged the lack of evidence addressing prioritized outcomes including 30-day major complications, need for emergency surgery, stoma-free survival at 1 year, and quality of life at 1 year. Given that patient values and preferences may vary, clinicians are encouraged to apply patient-centered decision-making and discuss the alternatives.

conclusionThis clinical practice guideline update provides evidence-informed recommendations to support patients and clinicians in the management of diverticular disease.

Indexed as

AntibioticsColonoscopyColorectal surgeryDiverticulitisGuidelinesLaparoscopic surgeryMesalamineMinimally invasive surgeryRifaximinSUDD

Identifiers

PMID42875633

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.